Use of Microneedle Device to Enhance Dermal Absorption: Study on Ex Vivo Human Skin
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چکیده
Skin constitutes an excellent barrier for the transdermal delivery of hydrophilic or high molecular weight drugs. Low efficacy demonstrated in clinical trials for some topical drugs is mainly due to low skin penetration ability related to the efficient barrier properties of stratum corneum (SC). Transdermal delivery of molecules in the skin is limited by the full epidermis, not just stratum corneum [1]. In order to overcome the skin barrier, different chemical and physical methodologies have been investigated to enhance skin penetration. Among the physical methods, one presents the perforation of the skin with microneedles (MN) that disrupts the barrier of the skin and creates pores inducing an increase of penetration. Microneedle technology offers an efficient and minimally invasive strategy to enhance transdermal drug delivery compared to conventional transdermal patches and intravenous injections [2-6].
منابع مشابه
Use of Microneedle Device to Enhance Dermal Absorption: Study on Ex Vivo Human Skin
Skin constitutes an excellent barrier for the transdermal delivery of hydrophilic or high molecular weight drugs. Low efficacy demonstrated in clinical trials for some topical drugs is mainly due to low skin penetration ability related to the efficient barrier properties of stratum corneum (SC). Transdermal delivery of molecules in the skin is limited by the full epidermis, not just stratum cor...
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